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Coadministration may potentiate the CNS-depressant effects of each drug. Either increases toxicity of the other by pharmacodynamic synergism. Institute health care for institute health care increased if flibanserin is coadministration with other CNS depressants.

Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

Coadministration of glycopyrronium tosylate 33 mx with other anticholinergic medications may result in additive anticholinergic adverse effects.

May enhance CNS depression. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect. Hydromorphone (diphenhydramine will increase the level or effect of hydromorphone by affecting hepatic enzyme CYP2D6 metabolism.

Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption.

Either increases toxicity of the other by Other (see comment). If concomitant use is necessary, may require less frequent oliceridine dosing. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. If inhibitor is discontinued, consider increase oliceridine dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. Either increases levels of the other by plasma protein binding competition. Comment: Coadministration of phenelzine and antihistamines may result in additive CNS depressant effects.

Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Inhibition of CYP2D6 metabolism to tamoxifen's active metabolite, endoxifen. Decreased conversion of tramadol to active metabolite.

Potential for additive anticholinergic effects. Either increases levels institute health care the other institute health care Mechanism: plasma protein binding competition. Decreased conversion of oxycodone to active metabolite morphine. Siberian ginseng increases effects of diphenhydramine by pharmacodynamic synergism.

Monitor Closely (1)diphenhydramine increases and albuterol decreases sedation. Monitor Closely (1)diphenhydramine and alfentanil both increase sedation.

Monitor Closely institute health care and alprazolam both increase sedation. Monitor Closely (1)diphenhydramine, amantadine. Monitor Closely (1)diphenhydramine increases toxicity of amifampridine by Other (see comment). Monitor Closely (1)diphenhydramine and amobarbital both increase sedation.

Monitor Closely (1)diphenhydramine and apomorphine both increase sedation. Monitor Closely (1)diphenhydramine increases and arformoterol decreases sedation. Monitor Closely (4)diphenhydramine decreases levels of aripiprazole by inhibition of GI absorption. Minor (1)diphenhydramine will increase the level or effect institute health care aripiprazole by affecting hepatic enzyme CYP2D6 metabolism.

Monitor Closely Varivax (Varicella Virus Vaccine Live)- Multum increases and armodafinil decreases sedation.



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