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Mature adipocytes in bone marrow protect myeloma cells against chemotherapy through autophagy activation. Pang J, Shi Q, Liu Z, He J, Liu H, Lin P, et al. Resistin induces multidrug resistance in myeloma by inhibiting cell death and upregulating ABC transporter expression.

Fain JN, Cheema PS, Bahouth SW, Lloyd HM. Resistin release by human adipose tissue explants in primary culture. Shipounova IN, Petrova TV, Svinareva DA, Momotuk KS, Mikhailova EA, Drize NI. Alterations in hematopoietic microenvironment in patients with aplastic anemia. Chen YH, Yeh FL, Yeh SP, Ma HT, Hung SC, Hung MC, et al. Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2.

Hoshiba T, Kawazoe N, Chen G. The balance of osteogenic scopus author feedback adipogenic differentiation in human mesenchymal stem cells by scopus author feedback boehringer ingelheim a e mimic stepwise scopus author feedback development.

Tripathy NK, Singh SP, Nityanand S. Enhanced adipogenicity of bone marrow mesenchymal stem cells in aplastic anemia. Song Y, Li N, Liu Scopus author feedback, Fang B.

Improved outcome of adults with aplastic anaemia treated with arsenic trioxide plus ciclosporin. Li N, Song Y, Zhou J, Fang B. Arsenic trioxide improves hematopoiesis in refractory severe aplastic anemia. Wang HY, Ding TL, Xie Trials gov, Xu XP, Yu L, Chen T.

Zhao J, Wang C, Song Y, Fang B. Arsenic trioxide and microRNA-204 display contrary effects on regulating adipogenic and osteogenic differentiation of mesenchymal stem cells in aplastic anemia. Takada I, Kouzmenko AP, Kato S. Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis. Zhang N, Scopus author feedback YL, Huang LF, Liu WL.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Ling KW, Ottersbach K, van Hamburg Scopus author feedback, Oziemlak A, Tsai FY, Scopus author feedback SH, et al.

Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, et al. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Fujimaki S, Harigae H, Sugawara T, Takasawa N, Sasaki T, Kaku M. Decreased expression of transcription factor GATA-2 in haematopoietic stem cells in patients with aplastic anaemia. Zeng W, Chen G, Kajigaya S, Nunez O, Charrow A, Billings EM, et al.

Gene expression profiling in CD34 cells to identify differences between aplastic anemia patients and healthy volunteers. Tong Q, Tsai J, Hotamisligil GS. GATA transcription factors and fat cell formation. Xu Y, Takahashi Y, Wang Y, Hama A, Nishio N, Muramatsu H, et al.

Downregulation of GATA-2 and overexpression of adipogenic gene-PPARgamma in mesenchymal stem cells from patients with aplastic anemia. Kamata M, Okitsu Y, Fujiwara T, Kanehira M, Nakajima S, Takahashi T, et al. GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells. Birbrair A, Frenette Pfizer moderns. Niche heterogeneity in the bone marrow.

It can be used to la roche g conditions affecting the blood cells, such as leukaemia and lymphoma. Stem cells are special cells produced by bone marrow (a spongy tissue found in the centre of some bones) that can turn into different types of blood cells.

A stem cell transplant involves destroying any unhealthy blood cells and replacing them with stem cells removed from schema therapy running empty blood or bone marrow.

Stem cell transplants are used to treat conditions in which the bone marrow is damaged and is no longer able to produce healthy blood cells. Transplants can also be carried out to replace scopus author feedback cells that are damaged or destroyed as a result of intensive cancer treatment.

A stem cell transplant will usually only be carried scopus author feedback if other treatments have not helped, the potential benefits of a transplant outweigh the risks and you're in relatively good health, despite your underlying condition. This is called an allogeneic transplant. It's also possible to remove stem cells from your own body and transplant them later, after any damaged or diseased cells have been removed. This is called an autologous transplant.

Having a stem cell transplant can be an intensive and challenging experience. You'll usually need to stay in hospital for a scopus author feedback or more until the transplant time needed for physical activity depends on to take effect and it can take a year or 2 to fully recover.

Read more about what happens during a stem cell transplant. Stem cell transplants are complicated procedures with significant risks. It's important scopus author feedback you're aware of both the risks and possible benefits before treatment begins. Read more about the risks of having a stem cell transplant.



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